Anticholinergic burden interacts with age and AIDS history to amplify frailty in people with HIV

Key Points

• This research aims to understand how anticholinergic burden influences frailty in people with HIV, especially among older adults and those with a history of AIDS.
• Analyzed the impact of anticholinergic burden on frailty in individuals with HIV.
• Examined the effects of age and history of AIDS on this relationship.
• Identified potential strategies for routine assessment and deprescribing.
• Anticholinergic burden is linked to increased frailty levels in people with HIV.
• Older individuals and those with severe immunosuppression exhibit heightened frailty linked to anticholinergic burden.
• Proposed routine assessment can potentially mitigate these effects through deprescribing.