Revealing hidden tissue architecture with mid-infrared dichroism photoacoustic microscopy

Key Points

• The research aims to develop a novel imaging technique for better visualization of tissue architecture.
• Combined mid-infrared excitation with polarization-resolved photoacoustics
• Used a label-free approach for visualization
• Termed the new framework MIR-DS-PAM
• Successfully visualized molecular composition in engineered tissues
• Demonstrated fiber alignment in tissues
• Indicated potential for improving analytical histopathology