This commentary will review the discovery of the 'Oxygen Effect', discuss problems associated with original and alternative models, and summarize a radiation-chemistry-based model that is relevant to interest in dose-modification. The radiation chemistry background to this model shows directly how radiation depletes oxygen (and other molecules) and that while this depletion is a part of the oxygen effect, it does not define it. Finally, the impact of a shift in half-maximal resistance on radiation protection by FLASH will be illustrated.
Cameron J Koch (Mon,) studied this question.
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