Elevated hs-CRP levels were significantly associated with coronary slow flow, with a mean difference of 1.95 mg/L compared to controls (95% CI, 1.03 to 2.88; p≤0.0001).
Meta-Analysis (n=3,231)
Yes
Are high-sensitivity C-reactive protein (hs-CRP) levels elevated in patients with coronary slow flow compared to healthy controls?
Patients with coronary slow flow exhibit significantly elevated hs-CRP levels compared to healthy controls, supporting the role of low-grade peripheral inflammation in the pathogenesis of the disease.
Effect estimate: MD 1.95 mg/L (95% CI 1.03 to 2.88)
Absolute Event Rate: 1.95% vs 0%
p-value: p=≤0.0001
Despite the unknown mechanisms of coronary slow flow (CSF), several studies have investigated the role of inflammation in CSF pathogenesis and evaluated the hs-CRP levels in these patients. Our meta-analysis aims to resolve the controversy in the results and draw a conclusion. All studies measuring hs-CRP in patients with CSF and controls were included after a systematic search. A random-effects meta-analysis was employed to calculate standardized mean differences, considering heterogeneity among the studies. The methodological quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS). Out of the 299 records, 31 cross-sectional studies were included in the systematic review. The meta-analysis of these eligible cross-sectional studies revealed a significant association between CSF and hs-CRP (MD: 1.95 mg/L; 95% CI, 1.03 to 2.88; p ≤ 0.0001). The heterogeneity was considerable among studies. Additionally, sensitivity analyses indicated that the meta-analysis models were robust. This meta-analysis suggests that patients with CSF exhibit significantly elevated hs-CRP levels compared to healthy controls, supporting the role of hs-CRP as a state marker of the disease. CRD42023359516
Zare et al. (Wed,) conducted a meta-analysis in Coronary slow flow (n=3,231). Elevated hs-CRP levels vs. Healthy controls with normal hs-CRP levels was evaluated on Difference in hs-CRP levels (mg/L) between CSF patients and controls (MD 1.95 mg/L, 95% CI 1.03 to 2.88, p=≤0.0001). Elevated hs-CRP levels were significantly associated with coronary slow flow, with a mean difference of 1.95 mg/L compared to controls (95% CI, 1.03 to 2.88; p≤0.0001).