What question did this study set out to answer?

The study aims to investigate the role of RGS19 in glioma prognosis and its relationship with immune cell infiltration.

February 28, 2026

RGS19 is associated with prognosis and immune infiltration in glioma: an integrated bioinformatics analysis.

Key Points

The study aims to investigate the role of RGS19 in glioma prognosis and its relationship with immune cell infiltration.
Conducted differential expression analysis of RGS genes in glioma.
Developed a nomogram using the 'rms' package to assess prognostic capabilities of RGS19.
Analyzed the correlation between RGS19 expression and immune infiltration using the TIMER website.
Performed GO and KEGG pathway analyses to identify signaling pathways related to RGS19.
Identified RGS19 as a gene correlated with glioma prognosis.
Found significant associations between RGS19 expression and immune cell infiltration.
Mapped potential signaling pathways associated with RGS19 using bioinformatics approaches.

Abstract

The regulator of G-protein signaling (RGS) family is involved in the malignant progression of several cancers, but has not been adequately studied in glioma. Six RGS genes with differential expression were evaluated using differential expression analysis. Four genes, including RGS19, which correlated with the prognosis, were screened. A nomogram was completed by the 'rms' package. The correlation between RGS19 and immune infiltration was analyzed using the TIMER website, the 'GSVA' and 'estimate' packages. The GO and KEGG annotation analyses were completed by the 'clusterProfiler' package to screen potential signaling pathways associated with RGS19.

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Authors

Guiyuan Wang

Bozhou Lin

Tao Wang

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Institutions

Fourth People's Hospital of Sichuan Province

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Cite this study

Wang et al. (Thu,) studied this question.

synapsesocial.com/papers/69a286950a974eb0d3c01ac3 — DOI: https://doi.org/10.1080/10255842.2026.2635006

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GSVA: gene set variation analysis for microarray and RNA-Seq data· 2013 · 16,369 citations
Primary brain tumours in adults· 2018 · 1,408 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Characterization of Distinct Immunophenotypes across Pediatric Brain Tumor Types· 2013 · 264 citations
The epidemiology of glioma in adults: a "state of the science" review· 2014 · 2,273 citations
DLGAP3 suppresses malignant behaviors of glioma cells via inhibiting RGS12-mediated MAPK/ERK signaling· 2024 · 1 citations
GSVA: gene set variation analysis for microarray and RNA-Seq data· 2013 · 16,369 citations
Primary brain tumours in adults· 2018 · 1,408 citations

RGS19 is associated with prognosis and immune infiltration in glioma: an integrated bioinformatics analysis.

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider