Copper-Catalyzed Domino C-C Coupling/Aza-Henry Reaction on Nitriles for the Synthesis of 4-Nitro-2-Chromene-3-Amines

Key Points

• The aim is to develop an efficient method for synthesizing 4-nitro-2-chromene-3-amines through a copper-catalyzed reaction.
• Heating 2-(2-haloaryloxy)acetonitriles with nitromethane
• Using DBU as a base
• Employing copper iodide as a catalyst
• Formation of 4-nitro-2-chromene-3-amines was achieved
• The reaction proceeds via a domino sequence
• The process suggests a novel synthetic pathway for amines