High systemic immune-inflammation index (SII) with cutoff >966×103/µL predicted NVP with 63.67% sensitivity and 68.35% specificity and was significantly associated with increased NVP risk (OR 1.187, 95% CI 1.138–1.239, p<0.001) in first trimester pregnant women.
Case-Control (n=556)
No
Do hemogram-derived inflammation indices (SII, SIRI, PIV) predict nausea and vomiting in pregnancy and the need for hospitalization?
High systemic immune-inflammation index (SII) and pan-immune inflammation value (PIV) are associated with an increased risk of developing nausea and vomiting in pregnancy.
Effect estimate: OR 1.187 for SII (per 105/µL increase), OR 1.103 for PIV (per 108/µL2 increase) (95% CI 1.138–1.239 for SII; 1.052–1.157 for PIV)
p-value: p=<0.001 for both
Objective: To investigate the association between inflammatory indices derived from complete blood count, including the systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune inflammation value (PIV), in predicting nausea and vomiting in pregnancy (NVP). Methods: Women diagnosed and treated for NVP at a tertiary care hospital between 2016 and 2021 were retrospectively analyzed. A total of 278 eligible patients with NVP and 278 gestational age-matched healthy pregnant women were included. Patients with NVP were categorized as having mild (n = 58), moderate (n = 140), or severe NVP (n = 80). Patients with moderate and severe NVP, who almost always required hospitalization, were grouped together and assigned to the inpatient treatment group. The groups were then compared. Results: SII and PIV were significantly higher in the NVP group than in the control group (p 966 × 103/μL (63.67% sensitivity, 68.35% specificity), showed the best discriminatory performance for predicting NVP (p < 0.001), but there was no significant difference among SII, SIRI, and PIV in predicting the need for hospitalization. Conclusions: Our results show that there may be an association between high SII and PIV and an increased risk of developing NVP. In the future, after sufficient research, among these complete blood count-based inflammatory indices, SII may become an important component of regression models used as a screening tool to predict NVP, particularly in cases requiring inpatient care.
Üçok et al. (Thu,) conducted a case-control in Pregnant women in the first trimester (≤14 weeks gestation) with nausea and vomiting in pregnancy (NVP) including mild, moderate, and severe (hyperemesis gravidarum, HG) versus gestational age-matched healthy pregnant women (n=556). High systemic immune-inflammation index (SII) and pan-immune inflammation value (PIV) measured from hemogram vs. Gestational age-matched healthy pregnant women without NVP was evaluated on Prediction of nausea and vomiting in pregnancy (NVP) using hemogram-derived inflammatory indices (SII, PIV) (OR 1.187 for SII (per 105/µL increase), OR 1.103 for PIV (per 108/µL2 increase), 95% CI 1.138–1.239 for SII; 1.052–1.157 for PIV, p=<0.001 for both). High systemic immune-inflammation index (SII) with cutoff >966×103/µL predicted NVP with 63.67% sensitivity and 68.35% specificity and was significantly associated with increased NVP risk (OR 1.187, 95% CI 1.138–1.239, p<0.001) in first trimester pregnant women.