What question did this study set out to answer?

This research aims to validate the thermodynamic principles behind the THRML drift model through multiple computational experiments.

March 1, 2026Open Access

THRML Experimental Validation: Crooks Ratio, Hysteresis, and Coupling Redirect in Drift Dynamics

Key Points

This research aims to validate the thermodynamic principles behind the THRML drift model through multiple computational experiments.
Conducted four computational experiments: FEEDBACK-01, SC-01, SC-02, and SH-01.
Validated parameters and constants related to drift dynamics and hysteresis.
Analyzed the Crooks phase-riding window and coupling redirect effects.
Calibrated constants were determined, including canonical parameters.
First-order hysteresis was characterized with various restoration cost multipliers.
Identified coupling-redirect Pe threshold for therapeutic constraints.

Abstract

Four computational experiments (FEEDBACK-01, SC-01, SC-02, SH-01) validating the thermodynamic physics underlying the THRML drift model. Publishes calibrated constants: canonical parameters (b_α=0. 867, b_γ=2. 244, cᵦero=0. 3866, η·τ=0. 05082, K=16), Crooks phase-riding window (Pe 3. 5–5. 0), first-order hysteresis with restoration cost multipliers (2. 08×/3. 00×/4. 32×), and coupling-redirect Pe threshold for therapeutic constraint architecture (γ=0. 2 → Pe=12, DBT window).

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