Cytotoxic Lesion of the Corpus Callosum in the Emer-Gency Department: Case Report

ABSTRACT The corpus callosum is the primary commissural area formed by white matter tracts that provides interhemispheric communication between the two cerebral hemispheres. In recent years, cytotoxic lesions observed in the splenium of the corpus callosum have been identified by Magnetic Resonance imaging (MRI). These lesions which are called cytotoxic lesions of the corpus callosum, are rare radiological findings that can be seen secondary to a wide range of diseases. We present a case of a patient presenting to the Emergency Department with left leg pain and numbness on the left side of the face, who had a cytotoxic lesion of the corpus callosum Case:A 31-year-old male patient presented to the emergency department with complaints of pain in his left leg and numbness in the left side of his face. The physical examination is normal. Vital signs are normal. The patient's diffusion MRI showed a cytotoxic lesion of the corpus callosum as a well-defined, oval lesion with hyperintense diffusion restriction in the central part of the corpus callosum, corresponding to a hypointense lesion on ADC. The patient was admitted to the neurology clinic for follow-up Discussion and conclusion Cytotoxic lesions of the corpus callosum are secondary lesions associated with drug therapy, malignancies, infections, subarachnoid hemorrhage, metabolic diseases, head trauma, and more recently, Coronavirus disease 2019 (COVID-19) Cases are usually asymptomatic, but may present with symptoms such as headache, confusion, seizures, and delirium.Although cerebrovascular disease is primarily considered when interpreting imaging in patients presenting to the emergency department with neurological complaints, cytotoxic lesions of the corpus callosum should be kept in mind, too KEYWORDS; Corpus Callosum, numbness, emergency service, magnetic resonance (MR), cytotoxic lesion