What question did this study set out to answer?

The response aims to clarify the assumptions of the proposed method and contrast it with existing tests.

March 1, 2026

Rejoinder to reader reaction “Comment on ‘Double robust conditional independence test for novel biomarkers given established risk factors with survival data’ by Lucas Kook”

Key Points

The response aims to clarify the assumptions of the proposed method and contrast it with existing tests.
Review of Dr. Kook's commentary.
Clarification of assumptions in the proposed method.
Comparison of methods with previously published tests.
Acknowledgment of valid points from the commentary.
Emphasis on strengths of the proposed method over alternatives.

Abstract

We thank Dr. Kook for his thoughtful and constructive discussion of our paper. We appreciate his careful examination of the assumptions underlying our proposed method, as well as the numerical comparison with the Transformation Model Generalised Covariance Measure test proposed by Kook et al. Below, we respond to the main points raised in the Comment.

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Cite This Study

Yang et al. (Wed,) studied this question.

synapsesocial.com/papers/69a3d89aec16d51705d2fa4d https://doi.org/https://doi.org/10.1093/biomtc/ujag038

Discussion

Journals

Biometrics

Institutions

The University of Texas MD Anderson Cancer Center

National Institute of Allergy and Infectious Diseases

East China Normal University

References and Citations

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