Reply to: “Considerations on statistical analysis of NHANES data in oral microbiome diversity and mortality study”

Key Points

• Mortality metrics are better understood when accounting for microbiome diversity, leading to important insights.
• The analysis found significant correlations between microbiome diversity and mortality outcomes across diverse populations.
• Observational analysis using NHANES data highlights the complexity of statistical methods applied to health research.
• Findings suggest improved methodological rigor may enable further discoveries in oral microbiome and mortality associations.