Tackling the interplay between the brain and kidneys: CYP2C19 mice as a preclinical tool for studying cognitive impairment in kidney disease?

Key Points

• Cognitive impairment is observed in the context of kidney disease, suggesting an important interplay between these systems.
• Findings indicate altered cognitive function linked to kidney disease in CYP2C19 mice, which serve as a model for testing interventions.
• Investigation utilized a preclinical model with targeted genetic features, emphasizing the relevance of CYP2C19 in understanding brain-kidney interactions.
• These insights support the need for further research on this interplay using specific preclinical models, highlighting potential therapeutic targets.