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PRES in the Setting of Mycophenolate Use for Lupus Nephritis: A Diagnostic Challenge with Therapeutic Implications | Synapse
March 3, 2026
PRES in the Setting of Mycophenolate Use for Lupus Nephritis: A Diagnostic Challenge with Therapeutic Implications
AB
Alyssa Breazeale
MM
Mark Megaly
PS
Pamraj Sharma
Key Points
Mycophenolate use may lead to posterior reversible encephalopathy syndrome (PRES) in lupus nephritis patients, complicating diagnosis.
The study identifies PRES as a critical diagnostic challenge, impacting the management of lupus nephritis patients treated with mycophenolate.
Assessment involved clinical observations and imaging studies to evaluate the relationship between mycophenolate and PRES symptoms.
These findings underscore the need for heightened awareness of PRES in lupus nephritis treatment protocols, especially when using mycophenolate.
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Breazeale et al. (Sat,) studied this question.
synapsesocial.com/papers/69a75a39c6e9836116a1fceb
https://doi.org/https://doi.org/10.1007/s42399-025-02242-2