March 3, 2026Open Access

Lipoprotein(a) Concentration and Achieving Target Values of Low-Density Lipoprotein Cholesterol Calculated by Different Equations

Key Points

Achieving target LDL-C concentrations shows high consistency without elevated triglycerides levels.
In patients with Lp(a) concentration ≥ 30 mg/dL, the Martin-Hopkins equation provides accurate LDL-C estimates.
The observation underscores the utility of the Sampson equation for Lp(a) levels ≥ 41 mg/dL in assessing cholesterol levels.
Highlights the importance of accurate LDL-C interpretation to prevent misclassification based on Lp(a) concentrations.

Abstract

Comparison of LDL-C concentrations calculated by Friedewald, Martin-Hopkins, and Sampson equations showed high consistency in patients without elevated triglycerides. The LDLcorr is reasonable to use in patients with Lp(a) concentration ≥ 30 and ≥41 mg/dL when using the Martin-Hopkins and Sampson equations, respectively. These data may help clinicians interpret LDL-C goal attainment in patients with elevated Lp(a) and avoid misclassification driven by the Lp(a)-cholesterol component.

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Lipoprotein(a) Concentration and Achieving Target Values of Low-Density Lipoprotein Cholesterol Calculated by Different Equations

Key Points

Abstract

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