Enhanced antiproliferative and anti-inflammatory effects of combined metformin, tadalafil, and tamsulosin in a rat model of testosterone-induced benign prostatic hyperplasia

Key Points

• The combined treatment demonstrates strong antiproliferative and anti-inflammatory effects, improving outcomes in benign prostatic hyperplasia.
• In the rat model, the combination resulted in a notable reduction of prostate gland size by about 40%.
• This was an observational study utilizing a rat model of testosterone-induced benign prostatic hyperplasia.
• The findings suggest that the combination therapy could lead to new treatment options, yet further studies in humans are needed.