Benzenoid ring C–H olefination of Coumarins under Rh(III)-catalysis: Synthesis, anti-inflammatory evaluation and in silico studies

Key Points

• The anti-inflammatory evaluation shows a significant reduction in inflammation markers after olefination with Rh(III) catalysis.
• Synthesis yields coumarins with enhanced biological activity, showing promise for therapeutic applications in inflammation.
• Analysis of in silico studies demonstrates molecular interactions that underline the enhanced anti-inflammatory effects.
• The findings highlight potential new therapeutic avenues, but clinical validation in human models remains essential.