Novel thiadiazole derivatives: synthesis, in silico, in vitro and in vivo evaluation of analgesic and anti-inflammatory activities

Key Points

• Analgesic and anti-inflammatory effects were significantly enhanced in novel thiadiazole derivatives, indicating strong therapeutic potential.
• In vivo tests showed an 80% reduction in pain response after treatment with specific thiadiazole derivatives and in vitro assays supported these findings.
• Synthesis involved a complex multi-step process leading to various thiadiazole compounds, assessed through multiple testing methods.
• The findings highlight the effectiveness of thiadiazole compounds, warranting further exploration in clinical studies for pain management.