Regulation of Colonic Macrophages and Type-17 and Regulatory T Cells in DSS-Colitis by Ibd-Associated Transcription Factor, Crem

Key Points

• CREM deletion reduced the severity of DSS colitis, enhancing colonic macrophages and RORγt+ T cells.
• The analysis showed that increases in regulatory T cells and Th17 cells are linked to reduced colitis severity.
• Investigation of CREM's role was conducted using a model of DSS colitis to examine its impact on immune cells.
• This study highlights the potential of targeting CREM to manage intestinal inflammation in IBD.