Efficacy and mechanisms of cisplatin and sulforaphane nanoparticles in alleviating cisplatin resistance in non-small cell lung cancer

Key Points

• Enhanced cisplatin resistance is alleviated by nanoparticles activating the ferroptosis pathway, reducing tumor growth.
• The study showcases nanoparticles' significant anti-tumor effects through new synthesized compounds improving drug delivery.
• Analysis of synthesized nanoparticles examines their role in counteracting cisplatin drug resistance in lung cancer models.
• These findings support innovative strategies to overcome drug resistance in non-small cell lung cancer treatment.