March 3, 2026

Evaluation of the Combined Therapeutic Potential of Turmeric and Donepezil on the Cholinergic System in a Mouse Model of AD-like Pathology

Key Points

Cognitive performance improved significantly in turmeric- and donepezil-treated mice, indicating therapeutic potential.
Both turmeric and donepezil showed similar effects on cognition in scopolamine-induced amnesia, suggesting efficacy of herbal therapies.
Assessment using a mouse model of Alzheimer's disease-like pathology explored the combined effects of the treatments.
Further optimization of doses and clinical trials are needed to validate these preliminary findings and their potential implications.

Abstract

Turmeric monotherapy improved cognitive performance similarly to donepezil monotherapy in scopolamine-induced amnesic mice. These preliminary findings require further research, including dose optimization and clinical trials, to establish their clinical relevance.

Bookmark

Cite This Study

Justin et al. (Mon,) studied this question.

synapsesocial.com/papers/69a75b1cc6e9836116a21d08 https://doi.org/https://doi.org/10.2174/0113894501433829251216060839

Bookmark