Gut bacteria composition in animal models of Parkinson’s disease: a systematic review and meta-analysis

Key Points

• Alterations in gut bacteria were observed in various animal models of Parkinson’s disease, indicating potential links to disease progression.
• The meta-analysis highlighted significant shifts in specific gut microbial compositions across different studies, emphasizing the need for standardized methodologies.
• Systematic review of animal models revealed a consistent pattern of gut dysbiosis associated with neurodegenerative changes in Parkinson’s disease.
• Findings may enable future therapeutic strategies targeting gut microbiota to improve outcomes in Parkinson’s disease.