Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

Key Points

• Decision-making is significantly affected by past fentanyl reinforcement, showcasing distinct results in males and females.
• Females demonstrated a different pattern in multi-step decision-making compared to males, highlighting notable sex-specific effects.
• Observational analysis examines the influence of fentanyl reinforcement history on decision-making processes between sexes.
• Results indicate that understanding these differences is critical for personalized treatment approaches.