The importance of staying within range: associations between tacrolimus intrapatient variability and kidney transplant outcomes

Key Points

• Poor post-transplant outcomes are linked to multiple markers of tacrolimus underexposure, indicating its critical role.
• Maintaining tacrolimus levels within the target therapeutic range is essential during the early post-transplant period.
• Analysis highlights significant associations between intrapatient variability in tacrolimus and long-term kidney transplant success.
• Maintaining therapeutic levels may enhance transplant longevity and overall patient health, emphasizing the need for monitoring.