ICAP-1 alternative splicing regulates Talin tension polarization in NSCLC durotaxis

Key Points

• Durotaxis was regulated by alternative splicing of ICAP-1, affecting talin polarization.
• Notably, the impact on talin was seen in non-small cell lung cancer cells.
• This assessment highlights a mechanistic relationship between splicing and cell movement behavior.
• Findings suggest that targeting ICAP-1 could influence non-small cell lung cancer metastasis.