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Myo-Inositol modulates AKT signalling, mitochondrial protein expression and intracellular Ca²⁺dynamics in human dermal fibroblasts | Synapse
March 3, 2026
Open Access
Myo-Inositol modulates AKT signalling, mitochondrial protein expression and intracellular Ca²⁺dynamics in human dermal fibroblasts
PZ
Paola Zanfardino
AA
Alessandro Amati
DI
Domenico Iacobellis
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Key Points
Myo-inositol enhances akT signalling and alters calcium dynamics in fibroblasts, indicating cellular modulation.
Key metrics show significant changes in mitochondrial protein expression and intracellular calcium levels with myo-inositol treatment.
Analysis of human dermal fibroblasts reveals myo-inositol's role in cellular signalling pathways related to cellular function and health.
This finding supports the potential use of myo-inositol in skincare, though further studies are needed for broader applications.
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Zanfardino et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c42c6e9836116a24f5d
https://doi.org/https://doi.org/10.1038/s41598-026-37423-z