March 3, 2026Open Access

Association of Serotonin Transporter Gene 5HTTLPR rs25531 Polymorphism With Escitalopram Efficacy in Patients With Major Depressive Disorder

Key Points

Patients with LL genotypes and LAA haplotype show improved escitalopram response compared to others.
Efficacy of escitalopram is significantly influenced by serotonin transporter and rs25531 polymorphisms in this context.
This analysis utilized genetic polymorphism assessments to gauge response to treatment in major depressive disorder.
Findings highlight the potential for personalized treatment strategies based on genetic makeup, necessitating further exploration.

Abstract

5HTTLPR and rs-25,531 polymorphisms significantly influenced escitalopram efficacy, and patients carrying LL genotypes with LALA haplotype and 2 L functional group have better treatment response to escitalopram therapy compared to other groups.

Association of Serotonin Transporter Gene 5HTTLPR rs25531 Polymorphism With Escitalopram Efficacy in Patients With Major Depressive Disorder

Key Points

Abstract

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