Hepatitis B virus (HBV) DNA is present as both cccDNA and integrated forms in kidney tissues of HBV surface antigen-negative patients with renal cell carcinoma | Synapse
March 3, 2026Open Access
Hepatitis B virus (HBV) DNA is present as both cccDNA and integrated forms in kidney tissues of HBV surface antigen-negative patients with renal cell carcinoma
Key Points
HBV DNA was found in renal cell carcinoma tissues, linking it to potential carcinogenesis.
In this study, 70% of samples showed both cccDNA and integrated forms of HBV DNA in kidney tissues.
Analysis observed the correlation between HBV presence and renal cell carcinoma occurrence among negative HBV surface antigen patients.
Findings imply that HBV may play a direct role in kidney cancer development, warranting further investigation.
Abstract
Intrarenal presence of HBV DNA is a frequently occurring event strongly associated with RCC, suggesting a potential direct role of HBV in renal carcinogenesis.