Modeling GABAergic hyperexcitability in sleep bruxism patient-derived brainstem neurons using a multielectrode array platform

Key Points

• GABAergic neurons from sleep bruxism patients show constitutive hyperexcitability and excessive GABA release, indicating dysregulation.
• Electrophysiological phenotypes were reliably quantified using a high-throughput multielectrode array platform, enhancing measurable insights.
• The findings provide a scalable framework for future therapeutic discovery targeting sleep bruxism-related mechanisms.
• This work highlights the potential for new interventions, emphasizing clinical relevance while noting the need for further validation.