A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women

Key Points

• Melatonin supplementation may lead to improved bone mineral density, but optimal dosing remains uncertain due to intervention variability.
• Evidence indicates a potential positive association for sleep and menopausal symptoms, but findings are inconclusive as of now.
• Systematic review and meta-analysis of randomized controlled trials involving melatonin supplements for menopausal women were conducted across various studies.
• Further large-scale randomized controlled trials are essential for clarifying these findings and establishing clear recommendations.

Abstract