Photothermal therapy synergizes with CD47 blockade by inducing calreticulin exposure and remodeling the tumor extracellular matrix in oral squamous cell carcinoma

Key Points

• Increased calreticulin exposure provides a stronger "eat me" signal for macrophages, enhancing immune response.
• Photothermal therapy decreases extracellular matrix components, promoting efficient macrophage infiltration into tumors.
• This dual strategy significantly boosts the effectiveness of CD47 blockade against oral squamous cell carcinoma.
• The findings suggest potential for improved combined therapies in cancer immunotherapy, pending further validation.