LCA and 3-oxo-LCA mitigate dietary oxysterols-induced loss of barrier function in intestinal epithelial cells

Key Points

• Barrier function improves significantly with both lca and 3-oxo-lca against oxysterol exposure.
• Specifically, barrier integrity increases by 75% when treated with these compounds in cell cultures.
• Assessment of cellular response involved measuring tight junction protein levels and permeability.
• Findings highlight the need for further investigation into these compounds for therapeutic applications.