The crosstalk between chaperone-mediated autophagy and apoptosis via ATM/p53-mitochondria-dependent signaling contributed to ischemia-induced cerebral injuries

Key Points

• Chaperone-mediated autophagy and apoptosis interact during ischemia, affecting cell survival mechanisms.
• Cerebral injuries are associated with the ATM/p53 pathway, which influences mitochondrial function.
• Assessment using signaling pathway analysis highlights the role of mitochondria in linking these processes.
• Findings suggest novel therapeutic avenues targeting autophagy and apoptosis pathways in brain ischemia.