Single-dose mSEB–mi3 nanoparticle vaccine elicits robust humoral immunity and protects mice against SEB intoxication and MRSA infection

Key Points

• The mSEB–mi3 nanoparticle vaccine leads to significant humoral immunity, enhancing protection against multiple infections.
• Mice vaccinated with mSEB–mi3 exhibit clear resistance to SEB intoxication and MRSA infection within two weeks.
• Evaluation utilized a nanoparticle-based vaccine approach, demonstrating its efficacy in inducing strong immune responses.
• The findings suggest that nanoparticle vaccines could play an essential role in combating bacterial infections globally.