Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures

Key Points

• Loss of function in TDP-43 is induced by seeded aggregation, impacting neuronal pathways.
• Among various biomarkers, early pathological signatures were observed related to TDP-43 aggregation.
• This analysis methodically assessed aggregation mechanisms, highlighting their biological implications.
• Such findings suggest further exploration of TDP-43 aggregation in understanding neurodegenerative diseases.