Cinnamaldehyde attenuates LPS-induced acute kidney injury by inhibiting ferroptosis via the Gsk3/Nrf2/Gpx4 pathway

Key Points

• Cinnamaldehyde effectively reduces LPS-induced acute kidney injury, demonstrating a protective effect.
• The protective mechanism is primarily through the inhibition of ferroptosis along the GSK3β/Nrf2/GPX4 pathway.
• Analysis highlights the potential for cinnamaldehyde as a targeted therapy for septic acute kidney injury.
• Future clinical tests are needed to validate these findings and confirm efficacy beyond laboratory settings.