Umbilical cord mesenchymal stem cell-derived exosomes delivered via a thermosensitive hydrogel ameliorate atopic dermatitis by mitigating keratinocyte mitochondrial damage through activating the Wnt/β-catenin pathway

Key Points

• Exosomes derived from umbilical cord stem cells significantly reduce keratinocyte mitochondrial damage in atopic dermatitis.
• The treatment group shows a 30% improvement in symptoms compared to controls over 4 weeks.
• Assessment using a thermosensitive hydrogel for exosome delivery indicates high bioavailability and sustained release.
• This approach may enable better management of atopic dermatitis pending clinical validation in larger populations.