Hyodeoxycholic acid in Arisaema Cum Bile can alleviate pentylenetetrazol-induced epilepsy by activating p53/Nrf2/GPX4 to inhibit ferroptosis

Key Points

• Hyodeoxycholic acid significantly reduces seizure frequency in the model of epilepsy, targeting ferroptosis pathways.
• Activation of the p53/Nrf2/GPX4 pathway enhances cellular defense mechanisms against oxidative stress.
• Analysis of pentylenetetrazol-induced epilepsy indicates potential benefits in ferroptosis inhibition.
• Findings may lead to new therapeutic strategies for managing epilepsy and neurodegenerative diseases.