Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review

Key Points

• Endoplasmic reticulum stress plays a significant pathological role in spinal cord injury, affecting recovery.
• Key evidence suggests that targeting pathways related to endoplasmic reticulum stress may improve functional outcomes.
• This systematic review analyzes existing studies to identify molecular targets for potential therapies.
• The findings highlight the need to explore novel treatment strategies to mitigate endoplasmic reticulum stress effects.