Aging and neuropathic pain: Mitochondria-to-glia cascade, system mechanisms, and therapeutic strategies

Key Points

• Neuropathic pain mechanisms are linked to mitochondrial dysfunction and glial activation, highlighting the aging effect.
• Key evidence suggests a cascading relationship between mitochondria and glial cells, influencing pain perception.
• This analysis of aging and pain mechanisms underscores the potential for targeted therapeutic strategies to alleviate symptoms.
• Understanding these interactions may enable the development of new therapies to address neuropathic pain in older adults.