March 3, 2026Phytomedicine1 citationsOpen Access

Pedunculoside ameliorates metabolic dysfunction-associated steatotic liver disease by targeting HNRNPA1 and modulating PPARα signaling pathway to enhance Mitochondrial Fatty Acid β-Oxidation

YZYang ZhouSuzhou Vocational Health College JCJingyun ChiSuzhou Vocational Health College XXXining XuSuzhou University of Science and Technology

Key Points

Fatty acid β-oxidation levels increase significantly with pedunculoside treatment, indicating its potential benefits.
Key evidence shows that pedunculoside stabilizes PPARα mRNA by binding to HNRNPA1, ultimately enhancing lipid metabolism.
This analysis investigates the interaction between pedunculoside, HNRNPA1, and PPARα signaling in metabolic liver disease.
Highlights the potential for targeting the HNRNPA1-PPARα pathway in treating metabolic dysfunctions in liver conditions.

Abstract

Our study uncovers a novel therapeutic axis in MASLD, in which PE enhances the stability of PPARα mRNA by directly binding to HNRNPA1, and consequently upregulates fatty acid β-oxidation. These findings not only position PE as a promising therapeutic candidate for MASLD but also identify the HNRNPA1-PPARα regulatory pathway as a potential mechanistic target for treating metabolic liver diseases.

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