Pharmacokinetics, therapeutic efficacy, and prolonged residue depletion of flumequine in Japanese eel (Anguilla japonica) and its implications for withdrawal period determination

Key Points

• Therapeutic efficacy of flumequine was demonstrated in Japanese eel, impacting treatment protocols.
• Flumequine exhibited a prolonged residue depletion of 31 days post-treatment, indicating safety concerns.
• Assessment included drug absorption, distribution, metabolism, and excretion analyses across numerous trials.
• Highlights the need for careful withdrawal period determination to ensure consumer safety and regulatory compliance.