Activation of the ATM–Chk2 DNA damage response pathway by Newcastle disease virus enhances viral replication

Key Points

• Enhanced viral replication results from the activation of the atm-chk2 pathway, indicating a critical mechanism in viral infections.
• Notably, activation led to a 30% increase in viral replication, emphasizing the pathway's role in the viral lifecycle.
• Analysis used experimental infection models to assess the impact of the atm-chk2 pathway activation on viral replication dynamics.
• Findings highlight that targeting this pathway may offer novel intervention strategies against Newcastle disease virus.