Why reproduction has probably been very problematic in Neanderthals: The fabulous history of (pre)eclampsia

Key Points

• Reproduction issues likely plagued Neanderthals, as high rates of preeclampsia affected fetal development.
• Preeclampsia was prevalent, potentially leading to adverse outcomes for both mothers and infants.
• This observational analysis identifies genetic factors and environmental influences contributing to reproductive complications.
• Findings may illuminate reasons for Neanderthal population decline, highlighting the impact of reproductive challenges.