Leukodystrophy-like phenotype in early-onset neuropsychiatric systemic lupus erythematosus: Case series and systematic review of the literature

Key Points

• The case series highlights a leukodystrophy-like phenotype associated with neuropsychiatric systemic lupus erythematosus.
• Symptoms developed in early childhood, with progressive neuropsychiatric features noted.
• Systematic review of literature complemented individual cases, revealing various presentations of the condition.
• Recognition of this phenotype is crucial for timely diagnosis and management of systemic lupus erythematosus.