Is Change in T cell Chimerism Predictive of Delayed Onset Severe GVHD?

Key Points

• Delayed onset severe graft-versus-host disease (GVHD) is significantly associated with T cell chimerism changes.
• A notable metric showed that 75% of subjects with altered chimerism experienced severe GVHD within six months.
• Observational analysis across various treatment centers evaluated T cell chimerism and GVHD incidence.
• The findings highlight the potential for T cell chimerism to serve as a biomarker in predicting GVHD outcomes.