NEDD4L knockdown enhances synovial fibroblast migration, invasion, and inflammatory factor secretion via Wnt/β-Catenin signaling activation

Key Points

• NEDD4L knockdown leads to increased migration and invasion of synovial fibroblasts, highlighting its role in cell movement.
• Increased secretion of inflammatory factors was observed, indicating a link between NEDD4L and inflammation.
• Activation of Wnt/β-Catenin signaling was crucial in mediating these effects, emphasizing a potential pathway for intervention.
• These findings may inform future treatments for conditions involving joint inflammation and synovial cell behavior.