A randomized controlled trial of cryoprobe versus forceps for transbronchial biopsy (FROSTBITE-2): Study protocol for a multi-center pragmatic clinical trial

Key Points

• Cryoprobe may offer advantages over forceps for transbronchial biopsy procedures, and shows promise in improving patient outcomes.
• The trial examines 300 patients in multiple centers to assess the effectiveness of two biopsy techniques.
• Randomized controlled trial protocol designed to facilitate comparisons of biopsy effectiveness across different clinical sites.
• Results can inform clinical practices, enhancing the quality of transbronchial biopsy techniques while outcomes are yet to be determined.