Biallelic LAMP3 Variants in Five Families with Interstitial Lung Disease: Evidence of a Disease-Gene Association

Key Points

• Interstitial lung disease was associated with biallelic variants in the LAMP3 gene across multiple families.
• Genetic analysis revealed these variants in five distinct families, highlighting their possible role in disease manifestation.
• Assessment included genetic sequencing to establish the connection between variants and disease symptoms within families.
• These findings support the notion that LAMP3 gene alterations may contribute to familial interstitial lung disease.