S-nitrosylation of Dexras1 attenuates fear memory generalization in the infralimbic cortex

Key Points

• Fear memory generalization is attenuated with S-nitrosylation of Dexras1 in the infralimbic cortex, influencing anxiety responses.
• Mice exhibited significant reductions in generalized fear responses, highlighting the impact of this molecular interaction on behavior.
• The approach involved manipulating S-nitrosylation levels of Dexras1, revealing new insights into its role in fear memory processes.
• This study suggests targeting S-nitrosylation could be a novel treatment strategy for anxiety-related disorders, warranting further exploration.