Magnetic Fe3O4-Au@UIO-66-NH2@toehold probe mediated fluorescent sensor for detecting ovarian cancer-specific circRNA coupled with hybridization chain reaction and the CRISPR-Cas12a system | Synapse
March 3, 2026
Magnetic Fe3O4-Au@UIO-66-NH2@toehold probe mediated fluorescent sensor for detecting ovarian cancer-specific circRNA coupled with hybridization chain reaction and the CRISPR-Cas12a system
Key Points
Detecting ovarian cancer-specific circRNA has been achieved using a fluorescent sensor.
The method combines hybridization chain reaction with the CRISPR-Cas12a system for enhanced sensitivity.
Employing Fe3O4-Au@UIO-66-NH2 nanoparticles improves detection accuracy of biomarkers.
The findings suggest a new avenue for developing precise cancer diagnostics, although clinical validation is needed.